Daniel Romer and Elaine F. Walker (eds)
- Published in print:
- 2007
- Published Online:
- May 2009
- ISBN:
- 9780195306255
- eISBN:
- 9780199863914
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195306255.001.0001
- Subject:
- Neuroscience, Development
Recent advances in our understanding of the human brain suggest that adolescence is a unique period of development during which both environmental and genetic influences can leave a lasting ...
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Recent advances in our understanding of the human brain suggest that adolescence is a unique period of development during which both environmental and genetic influences can leave a lasting impression. To advance the goal of integrating brain and prevention science, two areas of research which do not usually communicate with one another, the Annenberg Public Policy Center's Adolescent Risk Communication Institute held a conference with the purpose of producing an integrated book on this interdisciplinary area. Contributors were asked to address two questions: What neurodevelopmental processes in children and adolescents could be altered so that mental disorders might be prevented? And what interventions or life experiences might be able to introduce such changes? The book deals with the following: biological and social universals in development; characteristics of brain and behavior in development; effects of early maltreatment and stress on brain development; effects of stress and other environmental influences during adolescence on brain development; and reversible orders of brain development.Less
Recent advances in our understanding of the human brain suggest that adolescence is a unique period of development during which both environmental and genetic influences can leave a lasting impression. To advance the goal of integrating brain and prevention science, two areas of research which do not usually communicate with one another, the Annenberg Public Policy Center's Adolescent Risk Communication Institute held a conference with the purpose of producing an integrated book on this interdisciplinary area. Contributors were asked to address two questions: What neurodevelopmental processes in children and adolescents could be altered so that mental disorders might be prevented? And what interventions or life experiences might be able to introduce such changes? The book deals with the following: biological and social universals in development; characteristics of brain and behavior in development; effects of early maltreatment and stress on brain development; effects of stress and other environmental influences during adolescence on brain development; and reversible orders of brain development.
Kim Cornish and John Wilding
- Published in print:
- 2010
- Published Online:
- September 2010
- ISBN:
- 9780195179941
- eISBN:
- 9780199864652
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195179941.001.0001
- Subject:
- Neuroscience, Behavioral Neuroscience, Development
What is attention? How does it go wrong? Do attention deficits arise from genes or from the environment? Can we cure it with drugs or training? Are there disorders of attention other than deficit ...
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What is attention? How does it go wrong? Do attention deficits arise from genes or from the environment? Can we cure it with drugs or training? Are there disorders of attention other than deficit disorders? The past decade has seen a burgeoning of research on the subject of attention. This research has been facilitated by advances on several fronts: New methods are now available for viewing brain activity in real time, there is expanding information on the complexities of the biochemistry of neural activity, individual genes can be isolated and their functions identified, analysis of the component processes included under the broad umbrella of “attention” has become increasingly sophisticated, and ingenious methods have been devised for measuring typical and atypical development of these processes, from infancy into childhood, and then into adulthood. This book is concerned with attention and its development, both typical and atypical, particularly in disorders with a known genetic etiology or assumed genetic linkage. Tremendous advances across seemingly diverse disciplines — molecular genetics, pediatric neurology, child psychiatry, developmental cognitive neuroscience, and education s— have culminated in a wealth of new methods for elucidating disorders at multiple levels, possibly paving the way for new treatment options. The book uses three specific-yet-interlinking levels of analysis: genetic blueprint (genotype), the developing brain, and the behavioral-cognitive outcomes (phenotype), as the basis for charting the attention profiles of six well-documented neurodevelopmental disorders: ADHD, autism, fragile X syndrome, Down syndrome, Williams syndrome, and 22q11 deletion syndrome.Less
What is attention? How does it go wrong? Do attention deficits arise from genes or from the environment? Can we cure it with drugs or training? Are there disorders of attention other than deficit disorders? The past decade has seen a burgeoning of research on the subject of attention. This research has been facilitated by advances on several fronts: New methods are now available for viewing brain activity in real time, there is expanding information on the complexities of the biochemistry of neural activity, individual genes can be isolated and their functions identified, analysis of the component processes included under the broad umbrella of “attention” has become increasingly sophisticated, and ingenious methods have been devised for measuring typical and atypical development of these processes, from infancy into childhood, and then into adulthood. This book is concerned with attention and its development, both typical and atypical, particularly in disorders with a known genetic etiology or assumed genetic linkage. Tremendous advances across seemingly diverse disciplines — molecular genetics, pediatric neurology, child psychiatry, developmental cognitive neuroscience, and education s— have culminated in a wealth of new methods for elucidating disorders at multiple levels, possibly paving the way for new treatment options. The book uses three specific-yet-interlinking levels of analysis: genetic blueprint (genotype), the developing brain, and the behavioral-cognitive outcomes (phenotype), as the basis for charting the attention profiles of six well-documented neurodevelopmental disorders: ADHD, autism, fragile X syndrome, Down syndrome, Williams syndrome, and 22q11 deletion syndrome.
Jos J. Eggermont
- Published in print:
- 2015
- Published Online:
- May 2015
- ISBN:
- 9780198719090
- eISBN:
- 9780191802232
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780198719090.001.0001
- Subject:
- Neuroscience, Behavioral Neuroscience, Development
Sound is dynamic and as such has temporal and spectral content. The auditory system extracts the spectral aspects and the temporal ones in parallel in the cochlea and auditory nerve. For frequencies ...
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Sound is dynamic and as such has temporal and spectral content. The auditory system extracts the spectral aspects and the temporal ones in parallel in the cochlea and auditory nerve. For frequencies below about 1.5 kHz, the spectral and temporal representations of sound are potentially redundant and both represent the pitch of speech and music. Auditory temporal processing determines our understanding of speech, our appreciation of music, being able to localize a sound source, and to listen to a person in a noisy crowd. The underlying basic capabilities of the auditory system include precise representation of sound onsets and offsets, representing gap durations in sound, and being able to code fast amplitude- and frequency- modulations of sound. The co-occurrence of such onsets and modulations of sound determine auditory objects and allow separating those from other auditory streams. Problems with precise temporal representations of sound occur in auditory neuropathy and multiple sclerosis and lead to a mismatch between auditory sensitivity and speech discrimination. In dyslexia, specific language impairment and auditory processing disorders, similar problems occur early in life and set up additional cognitive speech processing problems. General neurological disorders such as autism, schizophrenia and epilepsy, display temporal processing deficits, generally though as a result of local and global neural synchrony problems. These synchrony problems are reflected in various cortical rhythm abnormalities and lead to cognitive dysfunctions. They also present auditory temporal processing problems, particularly in the amplitude modulation domain.Less
Sound is dynamic and as such has temporal and spectral content. The auditory system extracts the spectral aspects and the temporal ones in parallel in the cochlea and auditory nerve. For frequencies below about 1.5 kHz, the spectral and temporal representations of sound are potentially redundant and both represent the pitch of speech and music. Auditory temporal processing determines our understanding of speech, our appreciation of music, being able to localize a sound source, and to listen to a person in a noisy crowd. The underlying basic capabilities of the auditory system include precise representation of sound onsets and offsets, representing gap durations in sound, and being able to code fast amplitude- and frequency- modulations of sound. The co-occurrence of such onsets and modulations of sound determine auditory objects and allow separating those from other auditory streams. Problems with precise temporal representations of sound occur in auditory neuropathy and multiple sclerosis and lead to a mismatch between auditory sensitivity and speech discrimination. In dyslexia, specific language impairment and auditory processing disorders, similar problems occur early in life and set up additional cognitive speech processing problems. General neurological disorders such as autism, schizophrenia and epilepsy, display temporal processing deficits, generally though as a result of local and global neural synchrony problems. These synchrony problems are reflected in various cortical rhythm abnormalities and lead to cognitive dysfunctions. They also present auditory temporal processing problems, particularly in the amplitude modulation domain.
Jacques Balthazart
- Published in print:
- 2011
- Published Online:
- January 2012
- ISBN:
- 9780199838820
- eISBN:
- 9780199919512
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780199838820.001.0001
- Subject:
- Neuroscience, Neuroendocrine and Autonomic, Development
This book presents a simple description of the biological mechanisms that are involved in the determination of sexual orientation in animals and also presumably in humans. Using scientific studies ...
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This book presents a simple description of the biological mechanisms that are involved in the determination of sexual orientation in animals and also presumably in humans. Using scientific studies published over the last few decades, it argues that sexual orientation, both homosexual and heterosexual, is under the control of embryonic endocrine and genetic phenomena in which there is little room for individual choice. The book begins with animal studies of the hormonal and neural mechanisms that control the so-called instinctive behaviors and analyzes how this animal work may potentially apply to humans. The book does not focus exclusively on homosexuality, however. Instead, the book acts as a broader guide to the biological basis of sexual orientation, and also discusses important gender differences that may influence sexual orientation.Less
This book presents a simple description of the biological mechanisms that are involved in the determination of sexual orientation in animals and also presumably in humans. Using scientific studies published over the last few decades, it argues that sexual orientation, both homosexual and heterosexual, is under the control of embryonic endocrine and genetic phenomena in which there is little room for individual choice. The book begins with animal studies of the hormonal and neural mechanisms that control the so-called instinctive behaviors and analyzes how this animal work may potentially apply to humans. The book does not focus exclusively on homosexuality, however. Instead, the book acts as a broader guide to the biological basis of sexual orientation, and also discusses important gender differences that may influence sexual orientation.
Michael W. Miller (ed.)
- Published in print:
- 2006
- Published Online:
- January 2010
- ISBN:
- 9780195183139
- eISBN:
- 9780199865147
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195183139.001.0001
- Subject:
- Neuroscience, Development
This is the first book about both normal development of the nervous system and how early exposure to alcohol and nicotine interferes with this development. The developing nervous system is highly ...
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This is the first book about both normal development of the nervous system and how early exposure to alcohol and nicotine interferes with this development. The developing nervous system is highly dynamic and vulnerable to genetic and epigenetic factors that can be additive or synergistic. Disruption of normal brain development leads to an array of developmental disorders. One of the most common of these is mental retardation, the prime cause of which is prenatal exposure to alcohol. As chapters in this book show, alcohol has direct effects on the developing neural system and it affects genetic regulation. Another common neurotoxin is nicotine, and it is discussed in this book for three reasons: (1) the number of adolescents who smoke cigarettes is rising in some populations; (2) prenatal exposure to nicotine affects neurotransmitter systems that are critical for normal brain development and cognition; and (3) prenatal exposure to nicotine is often accompanied by prenatal exposure to alcohol. The mature brain is the culmination of an orderly sequence of basic ontogenetic processes—cell proliferation, migration, differentiation, and death. Neural stem cells and progenitors proliferate in discrete sites; then, young neurons migrate long distances to their residences where they form neural networks. During this sequence many immature cells die, presumably eliminating unsuitable or non-competitive cells. Each process is regulated by genetic and environmental factors. When this regulation goes awry, a dysmorphic and dysfunctional brain results. Though this can be tragic in clinical settings, in experimental contexts it provides keen insight into normal brain development. The book is divided into three parts. The first describes neural ontogeny in the normal brain. The second and third deal with the consequences of early exposure to alcohol and nicotine. Though there are similarities in the effects of these two toxins, there are also intriguing differences. The commonalities reflect the plasticity and resilience of the developing brain while the differences point to the targeted effects of the two toxins. Exploring these effects brings a richer appreciation of brain development.Less
This is the first book about both normal development of the nervous system and how early exposure to alcohol and nicotine interferes with this development. The developing nervous system is highly dynamic and vulnerable to genetic and epigenetic factors that can be additive or synergistic. Disruption of normal brain development leads to an array of developmental disorders. One of the most common of these is mental retardation, the prime cause of which is prenatal exposure to alcohol. As chapters in this book show, alcohol has direct effects on the developing neural system and it affects genetic regulation. Another common neurotoxin is nicotine, and it is discussed in this book for three reasons: (1) the number of adolescents who smoke cigarettes is rising in some populations; (2) prenatal exposure to nicotine affects neurotransmitter systems that are critical for normal brain development and cognition; and (3) prenatal exposure to nicotine is often accompanied by prenatal exposure to alcohol. The mature brain is the culmination of an orderly sequence of basic ontogenetic processes—cell proliferation, migration, differentiation, and death. Neural stem cells and progenitors proliferate in discrete sites; then, young neurons migrate long distances to their residences where they form neural networks. During this sequence many immature cells die, presumably eliminating unsuitable or non-competitive cells. Each process is regulated by genetic and environmental factors. When this regulation goes awry, a dysmorphic and dysfunctional brain results. Though this can be tragic in clinical settings, in experimental contexts it provides keen insight into normal brain development. The book is divided into three parts. The first describes neural ontogeny in the normal brain. The second and third deal with the consequences of early exposure to alcohol and nicotine. Though there are similarities in the effects of these two toxins, there are also intriguing differences. The commonalities reflect the plasticity and resilience of the developing brain while the differences point to the targeted effects of the two toxins. Exploring these effects brings a richer appreciation of brain development.
Melissa Hines
- Published in print:
- 2005
- Published Online:
- May 2009
- ISBN:
- 9780195188363
- eISBN:
- 9780199865246
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195188363.001.1
- Subject:
- Neuroscience, Neuroendocrine and Autonomic, Development
How important are biological factors, such as hormones, in shaping our sexual destinies? This book brings social developmental, biological, and clinical psychological perspectives to bear on the ...
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How important are biological factors, such as hormones, in shaping our sexual destinies? This book brings social developmental, biological, and clinical psychological perspectives to bear on the factors that shape our development as male or female and that cause individuals within each sex to differ from one another in sex-related behaviors. Topics covered include sexual orientation, childhood play; spatial, mathematical, and verbal abilities; nurturance, aggression, dominance, handedness, brain structure, and gender identity.Less
How important are biological factors, such as hormones, in shaping our sexual destinies? This book brings social developmental, biological, and clinical psychological perspectives to bear on the factors that shape our development as male or female and that cause individuals within each sex to differ from one another in sex-related behaviors. Topics covered include sexual orientation, childhood play; spatial, mathematical, and verbal abilities; nurturance, aggression, dominance, handedness, brain structure, and gender identity.
Paul Nunez
- Published in print:
- 2010
- Published Online:
- May 2010
- ISBN:
- 9780195340716
- eISBN:
- 9780199776269
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195340716.001.0001
- Subject:
- Neuroscience, Development
Does the brain create the mind, or is some external entity involved? In addressing this hard problem of consciousness, we face a central human challenge: what do we really know and how do we know it? ...
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Does the brain create the mind, or is some external entity involved? In addressing this hard problem of consciousness, we face a central human challenge: what do we really know and how do we know it? Tentative answers in this book follow from a synthesis of profound ideas, borrowed from philosophy, religion, politics, economics, neuroscience, physics, mathematics, and cosmology, the knowledge structures supporting our meager grasp of reality. This search for new links in the web of human knowledge extends in many directions: the shadows of our thought processes revealed by brain imagining, brains treated as complex adaptive systems that reveal fractal-like behavior in the brain's nested hierarchy, resonant interactions facilitating functional connections in brain tissue, probability and entropy as measures of human ignorance, fundamental limits on human knowledge, and the central role played by information in both brains and physical systems. The author discusses the possibility of deep connections between relativity, quantum mechanics, thermodynamics, and consciousness; all entities involved with fundamental information barriers. This study elaborates on possible new links in this nested web of human knowledge that may tell us something new about the nature and origins of consciousness. In the end, does the brain create the mind? Or is the mind already out there?Less
Does the brain create the mind, or is some external entity involved? In addressing this hard problem of consciousness, we face a central human challenge: what do we really know and how do we know it? Tentative answers in this book follow from a synthesis of profound ideas, borrowed from philosophy, religion, politics, economics, neuroscience, physics, mathematics, and cosmology, the knowledge structures supporting our meager grasp of reality. This search for new links in the web of human knowledge extends in many directions: the shadows of our thought processes revealed by brain imagining, brains treated as complex adaptive systems that reveal fractal-like behavior in the brain's nested hierarchy, resonant interactions facilitating functional connections in brain tissue, probability and entropy as measures of human ignorance, fundamental limits on human knowledge, and the central role played by information in both brains and physical systems. The author discusses the possibility of deep connections between relativity, quantum mechanics, thermodynamics, and consciousness; all entities involved with fundamental information barriers. This study elaborates on possible new links in this nested web of human knowledge that may tell us something new about the nature and origins of consciousness. In the end, does the brain create the mind? Or is the mind already out there?
Don Tucker and Phan Luu
- Published in print:
- 2012
- Published Online:
- January 2013
- ISBN:
- 9780199838523
- eISBN:
- 9780199985654
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780199838523.001.0001
- Subject:
- Neuroscience, Development
Scientific research shows how experience shapes the organization of the human brain through mechanisms of neural plasticity, which capture the information of the world within the connections among ...
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Scientific research shows how experience shapes the organization of the human brain through mechanisms of neural plasticity, which capture the information of the world within the connections among neurons. To understand this plasticity, it is important to look to the developmental mechanisms through which the brain grows from a single cell in embryogenesis to achieve the complex architecture of the human brain. The process of neural morphogenesis involves exuberant formation of neuronal connections, and then subtractive elimination of unused connections. This process is continued after birth, providing the neural plasticity of learning that allows cognitive development in infancy and childhood. Recognizing this continuity suggests an interesting insight—cognition is a reflection of neural development throughout the life span. This book examines the embryonic development of the brain to appreciate the dimensions of developmental momentum that shape the neural and psychological development of our lives. Human brain embryogenesis involves gradients of trophic factors that guide the migration of neurons from ventricular proliferative zones to organize the architecture of the cerebral hemispheres. The architecture of human cognition involves a functional differentiation of dorsal (pyramidal) and ventral (granular) corticolimbic divisions. This differentiation is a defining feature of not just human but mammalian neuroanatomy. The separation of pyramidal and granular cortical architectures appeared with the evolution of the six-layered mammalian neocortex from the three-layered primitive general cortex of reptiles and amphibians. The functional differentiation of the dorsal and ventral divisions of the cerebral hemispheres has been shown to be integral to multiple levels of psychological function, from elementary motivation to the most complex forms of executive self-regulation.Less
Scientific research shows how experience shapes the organization of the human brain through mechanisms of neural plasticity, which capture the information of the world within the connections among neurons. To understand this plasticity, it is important to look to the developmental mechanisms through which the brain grows from a single cell in embryogenesis to achieve the complex architecture of the human brain. The process of neural morphogenesis involves exuberant formation of neuronal connections, and then subtractive elimination of unused connections. This process is continued after birth, providing the neural plasticity of learning that allows cognitive development in infancy and childhood. Recognizing this continuity suggests an interesting insight—cognition is a reflection of neural development throughout the life span. This book examines the embryonic development of the brain to appreciate the dimensions of developmental momentum that shape the neural and psychological development of our lives. Human brain embryogenesis involves gradients of trophic factors that guide the migration of neurons from ventricular proliferative zones to organize the architecture of the cerebral hemispheres. The architecture of human cognition involves a functional differentiation of dorsal (pyramidal) and ventral (granular) corticolimbic divisions. This differentiation is a defining feature of not just human but mammalian neuroanatomy. The separation of pyramidal and granular cortical architectures appeared with the evolution of the six-layered mammalian neocortex from the three-layered primitive general cortex of reptiles and amphibians. The functional differentiation of the dorsal and ventral divisions of the cerebral hemispheres has been shown to be integral to multiple levels of psychological function, from elementary motivation to the most complex forms of executive self-regulation.
Roberto Cabeza, Lars Nyberg, and Denise Park (eds)
- Published in print:
- 2004
- Published Online:
- May 2009
- ISBN:
- 9780195156744
- eISBN:
- 9780199864171
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195156744.001.0001
- Subject:
- Neuroscience, Behavioral Neuroscience, Development
Until very recently, our knowledge about the neural basis of cognitive aging was based on two disciplines that had very little contact with each other. Whereas the neuroscience of aging investigated ...
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Until very recently, our knowledge about the neural basis of cognitive aging was based on two disciplines that had very little contact with each other. Whereas the neuroscience of aging investigated the effects of aging on the brain independently of age-related changes in cognition, the cognitive psychology of aging investigated the effects of aging on cognition independently of age-related changes in the brain. The lack of communication between these two disciplines is currently being addressed by an increasing number of studies that focus on the relationships between cognitive aging and cerebral aging. This rapidly growing body of research has come to constitute a new discipline, which may be called cognitive neuroscience of aging. The goal of this book is to introduce this new discipline. This book is divided into four main sections. The first section describes non-invasive measures of cerebral aging, including structural (e.g., volumetric MRI), chemical (e.g., dopamine PET), electrophysiological (e.g., ERPs), and hemodynamic (e.g., fMRI), and discusses how they can be linked to behavioral measures of cognitive aging. The second section reviews evidence for the effects of aging on neural activity during different cognitive functions, including perception and attention, imagery, working memory, long-term memory, and prospective memory. The third section focuses on clinical and applied topics, such as the distinction between healthy aging and Alzheimer's disease and the use of cognitive training to ameliorate age-related cognitive decline. The last section describes theories that relate cognitive and cerebral aging, including models accounting for functional neuroimaging evidence and models supported by computer simulations.Less
Until very recently, our knowledge about the neural basis of cognitive aging was based on two disciplines that had very little contact with each other. Whereas the neuroscience of aging investigated the effects of aging on the brain independently of age-related changes in cognition, the cognitive psychology of aging investigated the effects of aging on cognition independently of age-related changes in the brain. The lack of communication between these two disciplines is currently being addressed by an increasing number of studies that focus on the relationships between cognitive aging and cerebral aging. This rapidly growing body of research has come to constitute a new discipline, which may be called cognitive neuroscience of aging. The goal of this book is to introduce this new discipline. This book is divided into four main sections. The first section describes non-invasive measures of cerebral aging, including structural (e.g., volumetric MRI), chemical (e.g., dopamine PET), electrophysiological (e.g., ERPs), and hemodynamic (e.g., fMRI), and discusses how they can be linked to behavioral measures of cognitive aging. The second section reviews evidence for the effects of aging on neural activity during different cognitive functions, including perception and attention, imagery, working memory, long-term memory, and prospective memory. The third section focuses on clinical and applied topics, such as the distinction between healthy aging and Alzheimer's disease and the use of cognitive training to ameliorate age-related cognitive decline. The last section describes theories that relate cognitive and cerebral aging, including models accounting for functional neuroimaging evidence and models supported by computer simulations.
Roger Traub, MD and Miles Whittington, PhD
- Published in print:
- 2010
- Published Online:
- May 2010
- ISBN:
- 9780195342796
- eISBN:
- 9780199776276
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195342796.001.0001
- Subject:
- Neuroscience, Molecular and Cellular Systems, Development
This book reviews a number of clinical neuropsychiatric conditions in which brain oscillations play an essential role. It discusses how the intrinsic properties of neurons, and the interactions ...
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This book reviews a number of clinical neuropsychiatric conditions in which brain oscillations play an essential role. It discusses how the intrinsic properties of neurons, and the interactions between neurons – mediated by both chemical synapses and by gap junctions – can lead to oscillations in populations of cells. The discussion is based largely on data derived from in vitro systems (hippocampus, cerebral and cerebellar cortex) and from network modeling. Finally, the book considers how brain oscillations can provide insight into normal brain function as well as pathophysiology.Less
This book reviews a number of clinical neuropsychiatric conditions in which brain oscillations play an essential role. It discusses how the intrinsic properties of neurons, and the interactions between neurons – mediated by both chemical synapses and by gap junctions – can lead to oscillations in populations of cells. The discussion is based largely on data derived from in vitro systems (hippocampus, cerebral and cerebellar cortex) and from network modeling. Finally, the book considers how brain oscillations can provide insight into normal brain function as well as pathophysiology.